PhD Student - Exploring the evolution of vertebrate development using single-cell genomics
Centre For Genomic Regulation
Barcelona, Spain
hace 4 días
source : Euraxess

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.

The CRG shares principles of an interdisciplinary, motivated and creative scientific team that is supported by high-end and innovative technologies and a flexible and efficient administration.

In November 2013, the Centre for Genomic Regulation (CRG) received the ' logo from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the and the (Charter and Code).

The role

We are seeking a highly motivated candidate to join our teams to work on an interdisciplinary project (experimental and computational) involving single-cell genomics and chromatin profiling in different chordate species.

The research program for this position focuses on elucidating the origin and evolution of the regulatory programs controlling vertebrate morphogenesis and cell differentiation.

To this end, you will apply and analyse advanced functional genomics to characterize cell types and regulatory genome features in vertebrate and non-vertebrate chordate species.

Specifically, this involves : (i) scRNAseq to define cell type-specific gene expression across multiple developmental stages, and (ii) bulk ChIP-seq and ATAC-seq to map chromatin states and regulatory element usage.

The candidate will spearhead the analysis, integration, and interpretation of these comparative omics datasets.

About the team

Our groups study genome regulation from an evolutionary systems perspective. In particular, we are interested in deciphering the evolution of animal cell type developmental programs and the regulatory mechanisms underlying these programs.

To this end, we apply advanced single-cell genomics and chromatin experimental methods to molecularly dissect cell types and epigenomic landscapes in phylogenetically diverse organisms.

We also develop computational tools to integrate these diverse data sources into models of cell type gene regulatory networks and we use phylogenetic methods to comparatively analyze these models.

Our recent work has provided the first whole-organism cell type atlases in different species and mapped key regulatory features underlying both development and cell diversity in non-model invertebrate organisms and the origin of vertebrates (see "Relevant Publications" below).

By analysing the development of chordate species at single-cell resolution, we now aim at dissecting the evolution of vertebrate cellular ontogenies and their underlying gene regulatory networks.

For further information you can directly email the PIs of the groups : class "panel-body">

Offer Requirements

  • Skills / Qualifications

    Whom would we like to hire?

    Professional experience

    Must Have

  • You have experience in computational biology, in particular genomics and transcriptomics data analysis
  • You have experience working in Unix / Linux environments
  • You have experience in R statistical language
  • Desirable but not required

  • You have hands-on experience in basic molecular biology
  • You have hands-on experience in basic genomics workflows library preparation)
  • You have experience in chromatin experimental methods ChIP-seq, ATAC)
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