Two postdoc positions to analyze the ImpactT2D whole genome sequence cohort
Centre for Genomic Regulation (CRG)
Barcelona, ES
hace 5 días

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.

The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the '' Award from the European Commission.

This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the and the (Charter and Code).

The role

We invite applications for two highly motivated postdoctoral scientists to form part of a team that analyzes whole genome sequences in a large cohort of patients with type 2 diabetes.

One successful candidate will develop statistical models to incriminate rare and common genetic variants in diabetes susceptibility.

The other scientist will focus on developing methods to characterize small and large genome variants in this cohort. Both will work in a multicenter, multidisciplinary team named named ImpactT2D, which was recently funded by a Spanish Precision Medicine Initiative launched by the Carlos III Institute of Health.

ImpactT2D aims to develop transformative approaches for personalized medicine in type 2 diabetes.

The scientists will be based in the Centre for Genomic Regulation (CRG), Barcelona, in the Regulatory Genomics and Diabetes lab (Ferrer, Bonas-Guarch) jointly with the European Genome-phenome Archive / Universitat Pompeu Fabra team led by Navarro and Rambla.

Both postdoctoral scientists will work in a broader group of analysis teams from CRG, CNAG, European Genome-phenome Archive, CIC BioGune, and Universidad de Murcia, with expertise covering diverse areas such as genome sequence analysis, statistical genetics, machine learning or regulatory genomics.

The ImpactT2D consortium is also composed of outstanding clinical research centers across Spain.

About the lab

The overarching goal of the Regulatory Genomics and Diabetes lab is to understand the basis of gene regulation in pancreatic beta cells, and to deploy this knowledge to discover genetic causes and treatments for human diabetes.

The lab combines computational analysis of in-house and external genomic datasets including RNA-seq, ChIP, HiChIP, pcHiC, sc genomics,CRISPR screens, genome variant sequencing, along with human stem cell-based and animal model systems.

It is a multidisciplinary team that currently includes four computational scientists and six experimental scientists, many of whom carry their own genome data analysis.

Relevant published work from the team can be found in The lab has led studies that used regulatory maps in pancreatic islets to show how genetic regulatory DNA variants influence type 2 diabetes (Gaulton et al, Nature Genetics 2010, Pasquali et al, Nature Genetics 2014, Miguel Escalada et al, Nature Genetics 2019, Atla et al, Biorxiv 2021), built maps of the developing pancreas that helped uncover disease mutations and mechanisms of development (Cebola Nat Cell Biol 2015, Weedon et al Nature Genetics 2014), and characterized noncoding RNAs and their possible role in diabetes (Moran et al, Cell Metab 2012, Akerman et al Cell Metab 2017, Beucher et al, Biorxiv, 2021).

Whom would we like to hire?

Professional experience

Must Have

  • You have proven experience in programming competence in Python, R, or C++, or related languages, and Expertise in Linux and high-performance computing environments
  • You need to have experience in NGS data analysis to engage in a single cell genomics project
  • Desirable but not required / Nice to have

  • You have familiarity with methods in machine learning and / or statistical inference is desirable.
  • Education and training

  • You hold a PhD (or equivalent experience) in statistical genetics, genome sequence data analysis, or related fields
  • Languages

  • You are fluent in English
  • Competences

  • You have the ability to work both in a team and independently
  • You have the ability to work within a multidisciplinary environment
  • You have highly developed organizational skills
  • You are excellence driven
  • The Offer Working Conditions

  • Contract duration : 2 years, extendible.
  • Estimated annual gross salary : Salary is commensurate with qualifications and consistent with our pay scales.
  • Target start date : The post is available immediately, but the starting date is flexible.
  • We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities.

    To check out our training and development portfolio, please visit our website in the training section.

    We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

    The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

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