Joint PhD fellowship in cancer metastasis and diagnostic imaging
Donostia - San Sebastián, Spain
hace 4 días
source : Euraxess

Role of pro-inflammatory cytokines in breast cancer metastasis : New therapeutic and diagnostic strategies Project : Breast cancer is a highly prevalent health care problem.

Although 70% of the cases are cured, metastasis is the major contributor to the death of breast cancer patients; and management of metastatic breast cancer is a very important clinical challenge.

Cytokines are important players in inflammation, a process highly associated with tumour initiation, tumour maintenance, angiogenesis and metastasis.

In particular, interleukin 6-type cytokines, including IL-6 itself and Oncostatin M (OSM) have been recognized as important contributors to cancer progression.

Previous results from our groups show that the pro-inflammatory cytokine OSM plays an important role in metastasis and that it associates with decreased disease-free survival in breast cancer.

Primary tumours release extracellular vesicles (EVs) carrying malignant information that can travel throughout the body, and help colonizing other organs.

Importantly, EVs secreted by OSM-activated cells induce migration and invasion in vitro, suggesting that these EVs may promote tumour dissemination.

  • In this context, our research aims are : a) to investigate the role of OSM signalling, related cytokines and the OSM-induced EVs in preparing the metastatic niche and promoting metastasis;
  • b) to pre-clinically evaluate the potential benefit of anti-OSM : OSMR blocking antibodies in preventing or inhibiting metastasis;
  • and c) to find early biomarkers of metastasis and recurrence. To answer these questions, we will use a combination of complementary research approaches : relevant pre-clinical animal models (xenografts and genetic models of breast cancer), cutting-edge molecular and functional imaging techniques, cell culture experiments and histological and molecular analysis of clinical samples.

    Research group : The research will be conducted in a collaborative project between two leading research institutes. We are seeking an ambiotious and motivated student to advance our understanding of own changes at the molecular level impact animal physiology, health and lifespina.

    The work will be performed at Jesus Ruiz-Cabello group at CIC biomaGUNE (San Sebastian-Donostia) and María M. Caffarel s group at IIS Biodonostia (San Sebastian-Donostia).

    Both labs are in the same geographical area, separated by 15 minutes walk distance. The student will be enrolled in a PhD program at the University of the Basque Country as the degree awarding institution.

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