The team of Dr. Laura Mondragón at the Josep Carreras Leukaemia Research Institute is currently seeking for an enthusiastic Laboratory Technician in training to help them to validate new therapies for treating angioimmunoblastic T cell lymphoma employing murine and humanized murine animal models.

T-cell lymphomas are a group of rare hematological diseases with a poor prognosis and a high incidence of relapse after treatment.

This is the case of angioimmunoblastic T cell lymphoma. Availability of preclinical mouse models for rare cancers is a prerequisite for determining therapeutic pathways and targets from which to design and test new treatments.

The main objective of the project will be to contribute to the characterization of a new mouse model for the study of AITL by developing thymocytes maturation and T cell activation studies in order to determine possible defects in these processes leading to AITL appearance.

Then, we will study the molecular pathways implicated in this aberrant behavior with the objective to identify new therapeutic targets.

We will validate these new therapeutic targets employing immunodeprived in vivo mouse models with the final aim to achieve a specific, and effective therapy for treating AITL.

For more information, please visit our group webpage :

This position is founded by the project New therapeutic approach for treating angioimmunoblastic T cell lymphoma based on the discovery of a new Tfh population , that receives funding from the Hollis Brownstein Research Grants Program - New Investigator Blood Cancer Research Grant Program of the Leukemia Research Foundation.

What we need