Josep Carreras Leukaemia Research Institute (IJC)
hace 23 horas
source : Euraxess

We welcome applications from candidates eager to study the Epigenetics and immune disease at Research Group of Dr. Esteban Ballestar for the DOCTORAL to apply to the INPhINIT FELLOWSHIPS PROGRAMME.

The Epigenetics and immune disease group aim at understanding the role of epigenetic mechanisms in immune cell differentiation and in various context of immune function, with a particular focus on inflammation.

We also study the relevance of epigenetic alterations in immune-mediated disease including primary immunodeficiencies, autoimmune and autoinflammatory diseases.

We also investigate the impact of the epigenetic regulation of immune cells in the microtumour environment.

The PhD student will join a multidisciplinary and international team. The group has currently nine members () with a good balance between postdoctoral and predoctoral researchers and constitutes an excellent environment for the development of a scientific career.

This is exemplified by the achievements of previous PhD students who continued their careers in international laboratories (Babraham Institute, Wellcome Trust Sanger Institute, Blizard Institute), some of which have become successful group leaders.

Please also visit our group webpage :

The study matches the context of our laboratory research, which focuses on the study of the role, targeting mechanisms and functional consequences of epigenetic modifications in identity and function of immune cells.

  • Our group has developed several cellular models to investigate epigenetic mechanisms in myeloid differentiation Alvarez-Errico et al (2015) Nat Rev Immunol;
  • de la Rica et al (2013) Genome Biol; Vento-Tormo et al (2016) Genome Biol; Garcia-Gomez et al (2017) Nucleic Acis Res; Li et al (2020) Nucleic Acis Res , not only in physiological conditions but also under inflammatory situations or other pathological contexts those in cancer, autoimmune and autoinflammatory diseases and others Rodriguez-Ubreva et al (2019) Ann Rheum Dis;
  • Li et al (2020) Genome Med , such as the ones leading to the development of innate immune memory like in sepsis Lorente-Sorolla et al (2019) Genome Med .

    In addition to the study of experimental models, the team investigates the occurrence of aberrant epigenomic (methylome) profiles in the context of autoimmune and autoinflammatory diseases, as well as in certain types of primary immunodeficiencies.

    In these contexts, the group has pioneered the finding of epigenetic defects in these diseases. Examples include publications describing the presence of DNA methylation alterations in SLE Javierre et al (2010) Genome Res and common variable immunodeficiency Rodriguez-Cortez et al (2015) Nature Commun , using discordant pairs of monozygotic twins, and in Cryopyrin-Associated Periodic Syndromes (CAPS), an archetypical autoinflammatory disease Vento-Tormo et al (2016) J Allergy Clin Immunol .

    Offer Requirements

    Skills / Qualifications

    What we need?

    The team is engaged in active collaborations with national and international teams and the student will participate in those projects which provide a wide exposure to other research teams and other institutions.

    The position should be filled with a motivated molecular biologist, bioinformatician, geneticist or immunologist. Experience in molecular biology, cell biology and single-cell omic techniques will be valued.

    Alternatively, experience in immunological methods or in bioinformatics will also be valued.

  • The applications are submitted directly by the candidate to the la Caixa Foundation (Inphinit Incoming call). We highly recommend that in advanced the candidate contact with his future supervisor (if he is selected by la Caixa).
  • Take note that Josep Carreras’s positions are included under the umbrella of the Germans Trias I Pujol Research Institute (IGTP).
  • Check the Josep Carreras open position Inphinit Incoming call at

  • At the time of recruitment, candidates must comply with one of the following options :
  • 1. To have completed the studies that lead to an official Spanish or Portuguese (or from another country of the European Higher Education Area) university degree awarding 300 ECTS credits, of which at least 60 ECTS credits must correspond to master level.

    2. To have completed a degree in a non-Spanish or non-Portuguese university not adapted to the European Higher Education Area that gives access to doctoral studies.

    The verification of an equivalent level of studies to the ones mentioned above will be made by the university when the admission procedure starts.

  • Mobility Rule : For doing their research at Spanish institutions, candidates must have resided in Spain for less than 12 months in the last 3 years immediatelyprior to the closing date for submitting applications.
  • Short stays, such as holidays, done in a country other than their country of usual residence (where they carried out their main activity), will be considered as time spent in their country of usual residence.
  • Demonstrable level of English (B2 or higher).
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