Josep Carreras Leukaemia Research Institute (IJC)
hace 4 días
source : Euraxess

We welcome applications from candidates eager to study translational and clinical epigenetics data and to foster interactions with Oncologists, Hematologists, and Pathologists at Dr.

Esteller’s Cancer Epigenetics Group for the DOCTORAL to apply to the INPhINIT FELLOWSHIPS PROGRAMME.

Dr. Manel Esteller , Director at Josep Carreras Leukaemia Research Institute and principal investigator of the Cancer Epigenetics Group, is involved in the analysis of the type and mechanisms of epigenetic alterations in cancer cells, including aberrant changes in DNA methylation and histone modifications in cancer, the study of the epigenetics machinery and associated mutations, and finally, testing of epigenetic drugs.

Please also visit our group webpage

The Cancer Epigenetics Group's main research interests are :

  • Epigenetic disruption of mRNA transcription, particularly in DNA methylation and histone modification patterns, and its contribution to the initiation and progression of human tumours.
  • Translation of the use of epigenetic knowledge gained from research into biomarkers to predict clinical outcome and to assay new drugs to reverse the distorted epigenetic landscape.
  • Development and study of new epigenetic drugs that target DNA methylation and histone modification writers, readers and erasers and could have an anti-cancer effect.
  • Study of monogenic disorders affecting epigenetic genes, particularly in Rett syndrome.
  • Study of epigenomic profiles of common diseases such as cardiovascular alterations and Alzheimer and other neurodegenerative diseases.
  • Establishment of new epigenomic platforms to elaborate comprehensive DNA methylome maps.
  • In addition, the study of epitranscriptomics is a focus of intense research in the group.

    The PhD INPhINIT candidate will fit in any of the above described lines of research.

    Offer Requirements

    Skills / Qualifications

    What we need?

    We are looking for a young scientist with outstanding qualifications who wish to do her / his PhD in a stimulating scientific environment within the Biomedicine Area.

    Motivated molecular biologists, bioinformaticians, geneticists or immunologists are encouraged to apply. Experience in molecular biology techniques, cell biology or bioinformatics will be valued.

    The PhD student will join a multidisciplinary and international team. The group has a good balance between postdoctoral researchers, predoctoral fellows and technicians and constitutes an excellent environment for the development of a scientific career.

    This is exemplified by the achievements of previous PhD students who continued their careers in international laboratories , some of which have become successful independent group leaders.

  • The applications are submitted directly by the candidate to the la Caixa Foundation (Inphinit Incoming call). We highly recommend that in advanced the candidate contact with his future supervisor (if he is selected by la Caixa).
  • Take note that Josep Carreras’s positions are included under the umbrella of the Germans Trias I Pujol Research Institute (IGTP).
  • Check the Josep Carreras open position Inphinit Incoming call at

  • At the time of recruitment, candidates must comply with one of the following options :
  • 1. To have completed the studies that lead to an official Spanish or Portuguese (or from another country of the European Higher Education Area) university degree awarding 300 ECTS credits, of which at least 60 ECTS credits must correspond to master level.

    2. To have completed a degree in a non-Spanish or non-Portuguese university not adapted to the European Higher Education Area that gives access to doctoral studies.

    The verification of an equivalent level of studies to the ones mentioned above will be made by the university when the admission procedure starts.

  • Mobility Rule : For doing their research at Spanish institutions, candidates must have resided in Spain for less than 12 months in the last 3 years immediatelyprior to the closing date for submitting applications.
  • Short stays, such as holidays, done in a country other than their country of usual residence (where they carried out their main activity), will be considered as time spent in their country of usual residence.
  • Demonstrable level of English (B2 or higher).

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