Research Scientist - Medicinal Chemistry
Lilly
Madrid, ES
hace 1 día
source : DirectEmployers Association

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana.

Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism.

We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

For more than 140 years, Eli Lilly has been dedicated to meeting the health care needs of people around the world. We address these needs primarily by developing innovative medicines-investing heavily in research and development.

Lilly credits its exceptional employees for its success, and recognizes that the key to ongoing achievement lies in attracting and retaining the best people.

The Discovery Chemistry & Technologies organization within Lilly Research Laboratories is seeking a highly skilled scientist and team player to join the Medicinal Chemistry group based in Madrid, Spain.

Summary of the position : The successful candidate will : + Formulate hypothesis, design and synthetize novel small molecules to engage disease modifying targets and contribute decisively to the advancement of drug discovery programs from early lead generation to submission of candidate drugs to the clinic.

  • Leverage world-class structure-based drug design technologies and partner with expert colleagues in computational chemistry and biophysics to characterize protein-ligand interactions and gain key insights supporting de-novo molecular design.
  • Optimize lead compounds to improve potency, selectivity, physicochemical properties and DMPK to meet the desired target product profiles required to invent high-quality medicines.
  • Deliver high laboratory synthetic productivity to inform fast-paced SAR iterations through proposal and execution of synthetic routes.
  • Team up with colleagues specialized in high-throughput automated synthesis, route optimization and scale-up to maximize the overall efficiency and productivity of the group.
  • Reach out across disciplines to interact and collaborate with scientists in areas like pharmacology, translational science, ADME and toxicology to address specific program needs, increase your overall business acumen and provide them with Medicinal Chemistry perspectives.
  • Keep safety as top priority at any time, striving to maintain a strong safety culture. Qualifications : Required Education and Experience : + PhD in Organic Chemistry with demonstrated experience (2+ years) in small molecule organic synthesis and synthetic methodology, either in pharmaceutical industry or postdoctoral experience.
  • Strong Synthetic Organic Chemistry skills with deep and extensive working knowledge of modern synthetic chemistry methodologies, experimental work, isolation / purification techniques and structural analysis of synthetic organic molecules.
  • Ability to maintain awareness of latest literature of chemical transformations.+ Scientific creativity and ability to work independently solving problems through careful experimental design, analysis of complex data sets and mechanistic insight.

  • Robust track record of scientific contributions including peer reviewed publications, patents and presentations.+ Excellent English language oral and written communication skills, ability to engage highly effectively as team player in a multidisciplinary and international environment.
  • Proficient use of Microsoft Office applications as well as Scifinder, Reaxys or other scientific data tools to identify relevant scientific literature.
  • Strong work ethic. Scientific curiosity. Can do attitude.Additional desired skills : + Medicinal Chemistry expertise in pharmaceutical, biotechnology or academic environments, with strong knowledge of the following areas of Drug Discovery will be highly valued : + Structure-based drug design.
  • Lead optimization to improve potency, selectivity and properties of compounds.+ Drug metabolism and pharmacokinetics problem solving.
  • Computational chemistry tools and methods.+ Biophysical techniques such as X-ray crystallography.+ Command of scientific informatics and data visualization tools (e.
  • g. StarDrop, TIBCO Spotfire, KNIME) to undertake computationally enabled multi-property optimization approaches will be advantageous.

  • Ability to lead projects and initiatives, coordinating multiple scientific activities and team members simultaneously across various sites.
  • Other Information : Lilly is an EEO / Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

    Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively "Lilly") are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs.

    If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly Recruiting Compliance lists.

    lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process.

    Any other correspondence will not receive a response.Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

    At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world.

    How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.

    We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe! #WeAreLilly

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